A thread through the archive
Essays tagged “Alzheimer's disease”. Follow an idea across the archive.
A guest post defending the amyloid hypothesis of Alzheimer's disease, explaining why amyloid is likely the root cause despite recent criticism and discussing why early treatments have only been partially effective.
A detailed review of a 1995 paper introducing the PDAPP mouse model for Alzheimer's disease, examining how its limitations were overlooked and shaped decades of potentially misguided Alzheimer's research.
Scott Alexander critiques a study suggesting knowledge of ApoE4 gene status affects memory performance, arguing the results may be due to priming or stereotype threat rather than actual memory decline.